The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesis.

Brattig-Correia R*, Almeida JM*, Wyrwoll MJ*, Julca I, Sobral D, Misra CS, Di Persio S, Guilgur LG, Schuppe HC, Silva N, Prudêncio P, Nóvoa A, Leocádio AS, Bom J, Laurentino S, Mallo M, Kliesch S, Mutwil M, Rocha LM*, Tüttelmann F*, Becker JD*, Navarro-Costa P*
Elife, 10. Oktober 2024
Link zur Publikation.

Integration of long-read sequencing, DNA methylation and gene expression reveals heterogeneity in Y chromosome segment lengths in phenotypic males with 46,XX testicular disorder/difference of sex development.

Berglund A*, Johannsen EB*, Skakkebæk A, Chang S, Rohayem J, Laurentino S, Hørlyck A, Drue SO, Bak EN, Fedder J, Tüttelmann F, Gromoll J, Just J, Gravholt CH
Biology of Sex Differences, 8. Oktober 2024
Link zur Publikation.

Genome-wide DNA methylation changes in human spermatogenesis.

Siebert-Kuss LM*, Dietrich V*, Di Persio S, Bhaskaran J, Stehling M, Cremers JF, Sandmann S, Varghese J, Kliesch S, Schlatt S, Vaquerizas JM, Neuhaus N*, Laurentino S*
The American Journal of Human Genetics, 6. Juni 2024
Link zur Publikation.

OGRE: calculate, visualize, and analyze overlap between genomic input regions and public annotations.

Berres S, Gromoll J, Wöste M, Sandmann S, Laurentino S
BMC Bioinformatics, 26. Juli 2023
Link zur Publikation.

Transcriptome analyses in infertile men reveal germ cell–specific expression and splicing patterns.

Siebert-Kuss LM*, Krenz H*, Tekath T, Wöste M, Di Persio S, Terwort N, Wyrwoll MJ, Cremers JF, Wistuba J, Dugas M, Kliesch S, Schlatt S, Tüttelmann F, Gromoll J, Neuhaus N*, Laurentino S*
Life Science Alliance, 29. November 2022
Link zur Publikation.

Single-cell RNA-seq unravels alterations of the human spermatogonial stem cell compartment in patients with impaired spermatogenesis.

Di Persio S*, Tekath T*, Siebert-Kuss LM, Cremers JF, Wistuba J, Li X, Meyer zu Hörste G, Drexler HCA, Wyrwoll MJ, Tüttelmann F, Dugas M, Kliesch S, Schlatt S, Laurentino S*, Neuhaus N*
Cell Reports Medicine, 9. September 2021
Link zur Publikation.
 

Whole-genome methylation analysis of testicular germ cells from cryptozoospermic men points to recurrent and functionally relevant DNA methylation changes.

Di Persio S*, Leitão E*, Wöste M, Tekath T, Cremers JF, Dugas M, Li X, Meyer zu Hörste G, Kliesch S, Laurentino S, Neuhaus N, Horsthemke B
Clinical Epigenetics, 21. August 2021
Link zur Publikation.

A germ cell-specific ageing pattern in otherwise healthy men.

Laurentino S, Cremers JF, Horsthemke B, Tüttelmann F, Czeloth K, Zitzmann M, Pohl E, Rahmann S, Schröder C, Berres S, Redmann K, Krallmann C, Schlatt S, Kliesch S, Gromoll J
Aging Cell, 20. September 2020
Link zur Publikation.

wg-blimp: an end-to-end analysis pipeline for whole genome bisulfite sequencing data.

Wöste M, Leitão E, Laurentino S, Horsthemke B, Rahmann S, Schröder C
BMC Bioinformatics, 1. Mai 2020
Link zur Publikation.

High-resolution analysis of germ cells from men with sex chromosomal aneuploidies reveals normal transcriptome but impaired imprinting.

Laurentino S, Heckmann L, Di Persio S, Li X, Meyer Zu Hörste G, Wistuba J, Cremers JF, Gromoll J, Kliesch S, Schlatt S, Neuhaus N
Clinical Epigenetics, 28. August 2019
Link zur Publikation.