Dr. rer. nat. Sandra Laurentino


Gruppenleitung
Tel.: +49 (251) 83 - 57477
E-Mail: Sandra Laurentino
Research Gate


  • University training and degree

    2001 – 2006 Studies in Biochemistry (Licenciatura, pre-Bologna process), University of Beira Interior (UBI), Covilhã, Portugal

  • Advanced academic qualifications

    2011 Doctorate in Biomedicine, UBI

  • Postgraduate professional career

    2024 – Group Leader at the Institute of Reproductive Genetics, University of Münster
    2020 – 2024 Principal investigator CeRA (Centre of Reproductive Medicine and Andrology), University of Münster
    2012 – 2020 Post-doctoral researcher, CeRA, University of Münster

  • Academic memberships and activities

    2024 – EU COST Action 20119 'Andronet', Science Communication Coordinator
    2024 Paper of the Month of the Faculty of Medicine, University of Münster for the work “Genome-wide DNA methylation changes in human spermatogenesis”
    2021 – 2024 EU COST Action 20119 'Andronet', Science Communication Vice-Coordinator
    2022 'Young Researcher Award 2022' of the Network for Young Researchers in Andrology
    2021 Selected participant, 'Leadership journey for female researchers' (equal opportunity measures, DFG CRU326)
    2020 – Associate Editor 'Human Reproduction'
    2020 – Editorial Board Member 'Andrology'
    2019 Publication prize in Andrology of the DGU for the work “High-resolution analysis of germ cells from men with sex chromosomal aneuploidies reveals normal transcriptome but impaired imprinting”

  • Selected publications

    All publications by Dr. rer. nat. Sandra Laurentino can be found here.

    1. Berglund A*, Johannsen EB*, Skakkebæk A, Chang S, Rohayem J, Laurentino S, Hørlyck A, Drue SO, Bak EN, Fedder J, Tüttelmann F, Gromoll J, Just J, Gravholt CH. Integration of long-read sequencing, DNA methylation and gene expression reveals heterogeneity in Y chromosome segment lengths in phenotypic males with 46,XX testicular disorder/difference of sex development. Biol Sex Differ. 2024 Oct;15(1):77. doi: 10.1186/s13293-024-00654-8.
    2. Brattig-Correia R*, Almeida JM*, Wyrwoll MJ*, Julca I, Sobral D, Misra CS, Di Persio S, Guilgur LG, Schuppe HC, Silva N, Prudêncio P, Nóvoa A, Leocádio AS, Bom J, Laurentino S, Mallo M, Kliesch S, Mutwil M, Rocha LM*, Tüttelmann F*, Becker JD*, Navarro-Costa P*. The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesis. Elife. 2024 Oct;13:RP95774. doi: 10.7554/eLife.95774.
    3. Siebert-Kuss LM*, Dietrich V*, Di Persio S, Bhaskaran J, Stehling M, Cremers JF, Sandmann S, Varghese J, Kliesch S, Schlatt S, Vaquerizas JM, Neuhaus N*, Laurentino S*. Genome-wide DNA methylation changes in human spermatogenesis. Am J Hum Genet. 2024 May;S0002-9297(24)00132-0. doi: 10.1016/j.ajhg.2024.04.017.
    4. Siebert-Kuss LM*, Krenz H*, Tekath T, Wöste M, Di Persio S, Terwort N, Wyrwoll MJ, Cremers JF, Wistuba J, Dugas M, Kliesch S, Schlatt S, Tüttelmann F, Gromoll J, Neuhaus N*, Laurentino S*. Transcriptome analyses in infertile men reveal germ cell–specific expression and splicing patterns. Life Sci Alliance. 2023 Feb;6(2):e202201633. doi: 10.26508/lsa.202201633.
    5. Berres S, Gromoll J, Wöste M, Sandmann S, Laurentino S. OGRE: calculate, visualize, and analyze overlap between genomic input regions and public annotations. BMC Bioinformatics. 2023 Jul;24(1):300. doi: 10.1186/s12859-023-05422-w.
    6. Di Persio S*, Leitão E*, Wöste M, Tekath T, Cremers JF, Dugas M, Li X, Meyer zu Hörste G, Kliesch S, Laurentino S, Neuhaus N, Horsthemke B. Whole-genome methylation analysis of testicular germ cells from cryptozoospermic men points to recurrent and functionally relevant DNA methylation changes. Clin Epigenet. 2021 Dec;13(1):160. doi: 10.1186/s13148-021-01144-z.
    7. Di Persio S*, Tekath T*, Siebert-Kuss LM, Cremers JF, Wistuba J, Li X, Meyer zu Hörste G, Drexler HCA, Wyrwoll MJ, Tüttelmann F, Dugas M, Kliesch S, Schlatt S, Laurentino S*, Neuhaus N*. Single-cell RNA-seq unravels alterations of the human spermatogonial stem cell compartment in patients with impaired spermatogenesis. Cell Rep Med. 2021 Sep;2(9):100395. doi: 10.1016/j.xcrm.2021.100395.
    8. Laurentino S, Cremers JF, Horsthemke B, Tüttelmann F, Czeloth K, Zitzmann M, Pohl E, Rahmann S, Schröder C, Berres S, Redmann K, Krallmann C, Schlatt S, Kliesch S, Gromoll J. A germ cell-specific ageing pattern in otherwise healthy men. Aging Cell. 2020 Oct;19(10):e13242. doi: 10.1111/acel.1324.
    9. Wöste M, Leitão E, Laurentino S, Horsthemke B, Rahmann S, Schröder C. wg-blimp: an end-to-end analysis pipeline for whole genome bisulfite sequencing data. BMC Bioinformatics. 2020 May;21(1):169. doi: 10.1186/s12859-020-3470-5.
    10. Laurentino S, Heckmann L, Di Persio S, Li X, Meyer Zu Hörste G, Wistuba J, Cremers JF, Gromoll J, Kliesch S, Schlatt S, Neuhaus N. High-resolution analysis of germ cells from men with sex chromosomal aneuploidies reveals normal transcriptome but impaired imprinting. Clin Epigenetics. 2019 28;11(1):127. doi: 10.1186/s13148-019-0720-3.

    * contributed equally